Most of us have Microsoft Outlook at our day jobs.  Now Microsoft has provided a social connector where you can watch your facebook friends and interact with them while you are in Outlook; additionally you can use a plug in called Twinbox for twitter that is mentioned at the bottom of this post:

http://blogs.office.com/b/office_casual/archive/2010/07/13/outlook-gets-the-social-connector-see-how-you-can-facebook-while-reading-your-email.aspx